Keywords: Biomarkers, Metabolism, Cancer metabolism
Motivation: Glutamine plays essential roles in tumor growth and response to treatment.
Goal(s): To understand the impact of Gln depletion on cancer metabolism, we characterized metabolic alterations in pancreatic and breast cancer cells under Gln deprivation .
Approach: We used 1H MRS to understand the metabolic reprogramming caused by glutamine depletion in two pancreatic and two breast cancer cell lines.
Results: The changes in metabolism were accompanied by a significant reduction of cancer cell viability. Glutathione and succinate commonly decreased. We also observed, a significant increase of total choline, glycerophosphocholine and choline that may represent an adaptive metabolic response of cancer cells to glutamine depletion.
Impact: Targeting glutamine metabolism may offer a promising therapeutic approach, as acute glutamine depletion induces significant metabolic reprogramming in PDAC and breast cancer cells.
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