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Abstract #3024

Towards in vivo detection of bioimaging marker of neurogenesis process in murine embryo brain

Mariano Uberti1, Aditya N. Bade2, and Yutong Liu1
1Radiology, University of Nebraska Medical Center, Omaha, NE, United States, 2Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, United States

Synopsis

Keywords: Biomarkers, biomarkers, neurogenesis, embryo, Spectroscopy, CEST, mouse

Motivation: In vivo monitoring of neurogenesis process during embryonic development would aid in understanding brain formation, diagnosing developmental disorders, and testing therapeutic strategies.

Goal(s): To demonstrate the feasibility of combining 1H-MRS and CEST-MRI for specific in vivo detection of neurogenesis-linked oleic acid in a mouse embryo brain.

Approach: In vivo 1H-MRS and CEST MRI were performed on normal mouse brain at gestation day 17.5, and post-natal days 14, and 21.

Results: 1H-MRS detected overlapping peaks of lactate and oleic acid in vivo. CEST-MRI demonstrated feasibility to infer Lactate concentration in the region of interest, thus leading to oleic acid quantification.

Impact: Successful implementation of novel algorithm developed using complementary strength of 1H-MRS and CEST MRI to monitor oleic acid levels during embryonic development will provide a non-invasive tool that has a potential to elucidate the neurogenesis process.

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