Abstract #3025

Feasibility of BOLD, TOLD and 4D flow MRI for Assessment of Oxygen Consumption in Metabolic Dysfunction-Associated Steatotic Liver Disease

Raphael do Vale Souza¹, Jitka Starekova¹, Timothy J Colgan¹, Daiki Tamada¹, Alejandro Roldán-Alzate^1,2, Kevin M Johnson^1,3, Adnan Said⁴, Gesine Knobloch¹, Diego Hernando^1,3, and Scott B Reeder^1,3,5,6,7

¹Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Department of Gastroenterology, University of Wisconsin-Madison, Madison, WI, United States, ⁵Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁷Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Liver, biomarkers

Motivation: To evaluate oxygen consumption as a potential biomarker of MASLD.

Goal(s): Assess the feasibility of BOLD, TOLD and 4D Flow MRI to detect liver oxygen changes in patients with varying stages of MASLD.

Approach: Changes in R1, R2* and portal flow were compared across four conditions: 1) preprandial breathing room air, 2) preprandial breathing 100% O2, 3) postprandial breathing room air, and postprandial breathing 100% O2, in healthy controls and compared to patients with varying stages of MASLD.

Results: Changes in R2* significantly differed between controls (-9.8%) and advanced MASLD (-0.4%). O2 use showed a trend toward decreased portal flow in MASLD.

Impact: Oxygen consumption measurements made using quantitative MRI methods could serve as a potential biomarker for early, reversible changes in cellular function/metabolism in MASLD.

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