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Abstract #3026

Renal Spatial Profile of IVIM Parameters: Humans and Dogs

Luis Sanmiguel1,2,3, Amber Hillaert4, Pieter de Visschere1,2, and Pim Pullens1,3,5
1Department of Radiology and Nuclear Medicine, Ghent University Hospital, Gent, Belgium, 2Department of Diagnostic Sciences, Faculty of Medicine and Health Sciences, Ghent University, Gent, Belgium, 3Ghent Institute of Functional and Metabolic Imaging (GIFMI), Ghent University, Gent, Belgium, 4Department of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Ghent University, Gent, Belgium, 5IBiTech– Medisip, Ghent University, Gent, Belgium

Synopsis

Keywords: Kidney, IVIM, Phase, Contrast, Dog, PSV, EDV

Motivation: While renal IVIM is well-studied in humans, there is limited data for dogs and no direct human-dog comparisons. Understanding interspecies similarities and spatial heterogeneity in IVIM values could clarify the suitability of dogs as a model for human kidney research.

Goal(s):

  • Evaluate spatial heterogeneity of renal IVIM parameters across renal regions in both humans and dogs.
  • Identify interspecies similarities and differences.

Approach:

  1. Nine human participants and eight healthy beagles were scanned with similar DWI sequences (same b-values s/mm2).
  2. Divide each kidney in different anatomical regions.
  3. Evaluate IVIM parameters differences between regions.

Results: Significant differences were identified among different renal regions.

Impact: This study enhances understanding of IVIM parameter variation across renal regions from cortex to medulla and cranial-caudal direction in humans and dogs, providing insights into intrarenal diffusion dynamics and expands data availability for the IVIM canine community.

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Abstract

Keywords