Abstract #3039

The Role of DCE-MRI in Predicting Pathologic Complete Response After Neoadjuvant Chemotherapy in Rectal Cancer

Wen-jie FAN¹, Zi-qiang WEN², Quan-meng LIU², Yu-ru MA², Yi-yan LIU², Bao-lan LU², Jian-peng YUAN³, Yun-zhu WU⁴, Shen-ping YU², and Yan CHEN²

¹The First Affiliated Hospital, Sun Yat-sen University; The Seventh Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, ²Department of Radiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, ³Department of Radiology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, China, ⁴Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China

Synopsis

Keywords: Treatment Response, DSC & DCE Perfusion

Motivation: Neoadjuvant chemotherapy (NCT) benefits select locally advanced rectal cancer (LARC) patients, with those achieving clinical complete response (cCR) potentially avoiding surgery.

Goal(s): To evaluate the efficacy of dynamic contrast-enhanced MRI (DCE-MRI) parameters and MRI tumor regression grade (MR-TRG) in predicting pathologic complete response (pCR) after NCT.

Approach: Retrospective analysis of 81 rectal cancer patients, assessing DCE-MRI parameters and MR-TRG.

Results: K^trans and k_ep were significantly lower, while v_e was higher in pCR patients, with AUCs of 0.763, 0.868, and 0.698, respectively. MR-TRG showed high specificity but limited sensitivity.

Impact: This study highlights DCE-MRI’s potential in noninvasively predicting complete response in rectal cancer, supporting personalized, less invasive management and enabling organ preservation strategies in responsive patients following neoadjuvant chemotherapy.

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