Abstract #3045

Cardiac Function and 4D Flow in a Swine Model of Isolated Post-Capillary Pulmonary Hypertension

Timothy W Houston¹, Daniel Seiter¹, Timothy Hacker², Betty J Allen^3,4, Eric G Schmuck², Thekla Oecthering⁵, Andrew Wentland⁵, Diana Marcela Tabima Martinez⁴, Naomi C Chesler⁶, and Oliver Wieben^1,5

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Medicine, University of Wisconsin-Madison, Madison, WI, United States, ³Surgery, University of Wisconsin Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁵Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁶Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center and Biomedical Engineering, University of California, Irvine, Irvine, CA, United States

Synopsis

Keywords: Heart Failure, Modelling, left heart failure (LHF), pulmonary hypertension (PH), cardiac MR, 4D Flow, swine model, pulmonary vein banding

Motivation: Left heart failure (LHF) often results in pulmonary hypertension (PH), which leads to poorly understood pulmonary vascular and right ventricular changes caused by increased pulmonary venous pressures.

Goal(s): We utilized cardiac MRI (CMR) and right heart catheterization (RHC) metrics to better characterize this swine model of Ipc-PH without LHF and to analyze disease progression.

Approach: Surgical pulmonary vein banding of swine was performed to induce isolated post-capillary pulmonary hypertension (Ipc-PH) without damage to the left heart.

Results: A longitudinal comparison of CMR and RHC metrics showed the development of Ipc-PH independent of LHF with associated cardiopulmonary hemodynamic changes.

Impact: This swine model of isolated post-capillary PH demonstrates altered pulmonary venous return with elevated pulmonary vascular resistance and mean pulmonary artery pressure while preserving left ventricular ejection fraction, providing a potential means for evaluating progression to combined pre/post-capillary PH.

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