Abstract #3051

DTI Phenomapping of the Human Heart In Vivo and Ex Vivo

Christopher A. Rock^1,2, Iris Y Chen², Boris Keil^2,3, Christopher T. Nguyen^2,4,5, and David E. Sosnovik ^1,2,5

¹Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States, ²A.A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ³Institute of Medical Physics and Radiation Protection, TH Mittelhessen University of Applied Sciences, Geissen, Germany, ⁴Cardiovascular Innovation Research Center, Cleveland Clinic, Cleveland, OH, United States, ⁵Health Sciences and Technology Program, Harvard - Massachusetts Institute of Technology, Cambridge, MA, United States

Synopsis

Keywords: Myocardium, Tissue Characterization

Motivation: We sought to validate our approach of acquiring and characterizing myocardial microstructure through voxel-scale phenomapping of the human heart in vivo.

Goal(s): Our goal was to validate our approach using a high-quality ex vivo data set.

Approach: We used the voxels from diffusion tensor MRI scans of human hearts ex vivo and characterized the resulting phenomapping matrices.

Results: The in vivo and ex vivo hearts showed comparable helix angle derived metrics and presented similar trends for principal component analysis and k-means clustering.

Impact: DTI phenomapping of the human in vivo and ex vivo yielded near identical results, validating the accuracy of the technique to characterize myocardial microstructure.

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