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Abstract #3052

Whole heart diffusion tensor CMR using commercial ultrahigh performance whole body gradients

Andrew Scott1,2, Pedro Ferreira1,2, Rick Wage2, Karl Kunze3, Dudley Pennell1,2, and Sonia Nielles-Vallespin1,2
1National Heart and Lung Institute, Imperial College London, London, United Kingdom, 2CMR Unit, Royal Brompton Hospital, London, United Kingdom, 3MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom

Synopsis

Keywords: Myocardium, Acquisition Methods

Motivation: Efficient whole heart noninvasive assessment of the cardiac microstructure has great prognostic and diagnostic potential, but current techniques are typically limited to sparsely distributed slices.

Goal(s): Demonstrate whole heart diffusion tensor cardiovascular magnetic resonance (DT-CMR) in a clinically feasible scan time.

Approach: Motion compensated spin echo (MCSE) acquisitions were performed with interleaved slice imaging and 2D RF pulses using a whole body ultrahigh strength gradient system in 20 healthy volunteers

Results: Whole heart data was acquired in <25minutes demonstrating systematic differences in microstructural parameters across the LV myocardium.

Impact: Ultrahigh strength gradient enabled whole heart DT-CMR will enable assessment of pathological localised changes in cardiac microstructure.

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Keywords