Meeting Banner
Abstract #3053

MRI Characterization of Intrathrombus Transport and Flow During Vessel Occlusion

Cody J Kubicki1, Thomas Neuberger2, and Keefe B Manning3,4
1Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States, 2Huck Institute of the Life Sciences, The Pennsylvania State University, Univerity Park, PA, United States, 3Biomedical Engineering, The Pennsylvania State University, Univerity Park, PA, United States, 4Department of Surgery, Penn State Hershey Medical Center, Hershey, PA, United States

Synopsis

Keywords: Flow, Stroke

Motivation: Intrathrombus transport mechanisms are important to model accurately and to validate thrombolytic behavior but are understudied and not well characterized experimentally.

Goal(s): Previous models have largely ignored effective porous diffusivity and used unvalidated porosity-permeability relationships. Our goal is to provide new experimental data to help eliminate or validate these assumptions.

Approach: This study aims to use novel MRI applications to quantify intrathrombus convection and diffusion by tracking contrast agent movement through different clot types.

Results: Initial results demonstrated we can quantify spatially and temporally varying permeability during dissolution. We also observed decreased diffusivity compared to previously reported values.

Impact: Understanding intrathrombus transport mechanisms will provide researchers a better understanding of thrombolytic therapy failure and success. These data can be used to explain why certain clots are clinically more resistant to thrombolytics and to help build better predictive computational models.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords