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Abstract #3056

MR microscopy of cardiac microstructure with diffusion and structural tensor imaging in high-performance clinical and pre-clinical MR scanners

Camila Munoz1,2, Alberto Di Biase1,2, Karen P McCarthy3, Nicoleta Baxan1, Karl P Kunze4, Peter Speier5, Andreas Krug5, Dudley J Pennell1,2, Andrew D Scott1,2, Pedro F Ferreira1,2, and Sonia Nielles-Vallespin1,2
1National Heart and Lung Institute, Imperial College London, London, United Kingdom, 2CMR Unit, Royal Brompton and Harefield Hospitals, London, United Kingdom, 3Cardiac Morphology Unit, Royal Brompton and Harefield Hospitals, London, United Kingdom, 4MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 5Siemens Healthcare, Erlangen, Germany

Synopsis

Keywords: Microstructure, Microstructure, Cardiac microstructure

Motivation: Optical microscopy is limited to small tissue samples, lacking volumetric coverage to study the complex three-dimensional microstructure of the heart.

Goal(s): To develop an approach for whole-heart MR microscopy of human samples in an ultrahigh performance clinical MRI scanner, with enhanced imaging of transmural samples in a preclinical MRI system.

Approach: We introduce 3D TSE and GRE imaging protocols for whole-heart and transmural tissue samples and demonstrate the ability of this approach to depict microstructure through structural tensor analysis compared to high-resolution diffusion tensor analysis.

Results: High-resolution 3D TSE and GRE data delivers non-destructive imaging of the heart at the mesoscopic scale.

Impact: High-resolution 3D MR imaging of the heart, with each voxel containing a few tens of cells, can further our understanding of cardiac microstructure in health and disease. These advances pave the way for non-destructive whole-heart MR microscopy in large samples.

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Keywords