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Abstract #3061

Translation of Hyperpolarized [13C,15N2]Urea MRI for Novel Human Brain Perfusion Studies

Yaewon Kim1, Hsin-Yu Chen1, Tanner Nickles1, Illia Shkliar1, Duy Dang1, James Slater1, Charlie Wang1, Jeremy W. Gordon1, Chou T Tan2, Chris Suszczynski2, Sri Maddali2, Adam Gaunt3, Rui Chen3, Javier Villanueva-Meyer1, Duan Xu1, Peder E.Z. Larson1, John Kurhanewicz1, Robert A Bok1, Susan Chang4, and Daniel B Vigneron1,4
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2ISOTEC Stable Isotope Division, MilliporeSigma, Merck KGaA, Miamisburg, OH, United States, 3General Electric Healthcare, Niskayuna, NY, United States, 4Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Molecular Imaging, Contrast Agents, Brain, Translational Studies

Motivation: Motivated by the need for safe, non-invasive perfusion imaging, this study developed sterile, hyperpolarized [13C,15N2]urea as a novel MR molecular imaging probe for brain imaging.

Goal(s): We aimed to develop and apply a sterile hyperpolarized [13C,15N2]urea for human brain imaging, optimizing its use for detailed visualization of brain vasculature.

Approach: A new approach was implemented to produce hyperpolarized [13C,15N2]urea sterile doses, and hyperpolarized [13C,15N2]urea imaging was conducted in healthy brain volunteers.

Results: A sterile single-agent hyperpolarized [13C,15N2]urea probe was produced, enabling first-in-human 13C imaging of cerebral blood flow, depicting clear vascular structures and consistent arterial and venous signals across subjects.

Impact: First-in-human brain MRI studies with single-agent hyperpolarized [13C,15N2]urea effectively visualized brain vasculature, including arterial and venous circulation. This study lays the groundwork for clinical translation, opening possibilities for perfusion imaging in neurological and systemic conditions.

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Keywords