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Abstract #3066

DCE-MRI enables quantitative assessment of microvascular differences in chronic lung allograft rejection post-lung transplantation

Antonia Susnjar1,2, Marvah Hill Pierre-Louis3, Margaret Allison3, Abimbola Akinniyi1, Peter Caravan1,2, Iris Y. Zhou1,2, and Sydney Montesi2
1Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 3Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, United States

Synopsis

Keywords: Molecular Imaging, Contrast Mechanisms, DCE-MRI

Motivation: Chronic lung allograft dysfunction (CLAD) is a major cause of mortality after the first year post-lung transplant, with limited treatment options and challenges in early diagnosis.

Goal(s): Motivated by the need for non-invasive detection methods, this study aimed to assess microvascular perfusion and extracellular extravascular space changes in CLAD using dynamic contrast-enhanced MRI (DCE-MRI).

Approach: Using a free-breathing lung-specific DCE-MRI protocol, we compared lung transplant patients with and without CLAD.

Results: Our findings suggest DCE-MRI can detect alternations in lung perfusion and permeability, as well as extravascular space expansion between the two cohorts.

Impact: In this study, we report distinct differences in model-free quantification of contrast kinetics in lung transplant recipients with CLAD compared to those without, as assessed by DCE-MRI.

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