Keywords: Molecular Imaging, Contrast Mechanisms, DCE-MRI
Motivation: Chronic lung allograft dysfunction (CLAD) is a major cause of mortality after the first year post-lung transplant, with limited treatment options and challenges in early diagnosis.
Goal(s): Motivated by the need for non-invasive detection methods, this study aimed to assess microvascular perfusion and extracellular extravascular space changes in CLAD using dynamic contrast-enhanced MRI (DCE-MRI).
Approach: Using a free-breathing lung-specific DCE-MRI protocol, we compared lung transplant patients with and without CLAD.
Results: Our findings suggest DCE-MRI can detect alternations in lung perfusion and permeability, as well as extravascular space expansion between the two cohorts.
Impact: In this study, we report distinct differences in model-free quantification of contrast kinetics in lung transplant recipients with CLAD compared to those without, as assessed by DCE-MRI.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords