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Abstract #3069

Activated microglia indicated by PET-[11C]PBR28 binding in multiple sclerosis correlates with MRI measures of inflammation and demyelination

Irene Vavasour1,2, Nasim Vafai3, Elham Shahinfard3, Philippe Beauchemin4, Cornelia Laule1,2,5,6, Anthony Traboulsee3, Vesna Sossi3,6, Robert Carruthers3, and Shannon Kolind1,2,3,6
1Radiology, University of British Columbia, Vancouver, BC, Canada, 2International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, BC, Canada, 3Medicine, University of British Columbia, Vancouver, BC, Canada, 4Medicine, Université Laval, Quebec City, QC, Canada, 5Pathology & Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada, 6Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Multiple Sclerosis, PET/MR, Multiple sclerosis

Motivation: [11C]PBR28-PET can detect translocator protein, a marker for activated microglia. Advanced MR techniques are sensitive to different tissue properties such as myelin, axons and gliosis.

Goal(s): The goals of our study were to compare the binding of [11C]PBR28 in lesions and NAWM in different MS subtypes and to determine the correlation between [11C]PBR28 binding and advanced MRI metrics in NAWM.

Approach: Thirteen people living with MS and 5 controls were scanned with [11C]PBR28-PET and advanced 3T MRI.

Results: NAWM [11C]PBR28 differed significantly between MS and controls. Correlations were found between 11C]PBR28 binding and MR measures of myelin and gliosis.

Impact: Increased inflammation and gliosis may be driving demyelination, especially in progressive forms of multiple sclerosis. The ability to measure diffuse inflammation using PET-[11C]PBR28 and MRI could allow monitoring of therapies designed to target immune activity within the whole brain.

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Abstract

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