Abstract #3070

Optimizing of Flourine-19 at 7T MRI in large animal model after Acute Myocardial infarction.

Marwan hamid¹, Maxim Terekhov ¹, Rebekka Grampp ², Anja Stadtmüller², Mohammedreza Keshtkar ¹, Ibrahim Elabyad ¹, Sofia Dembski³, Gabriele Ulm³, Anna Frey², Ulrich Hofmann ², Wolfgang Bauer², and Laura M. Schreiber ¹

¹Chair of Molecular and Cellular Imaging, Comprehensive Heart Failure Center, University Hospital Wuerzburg, Würzburg, Germany, ²Department of Internal Medicine I, Cardiology, University Hospital Wuerzburg, Würzburg, Germany, ³Translational Center Regenerative Therapies TLC-RT, Fraunhofer Institute for Silicate Research ISC, Würzburg, Germany

Synopsis

Keywords: Inflammation, Infiltration, High-Field MRI, 19F MRI, 7T MRI, heart infarction, AMI

Motivation: Fluorine MRI has been used to track the fate of immune cells , as well as raised widespread interest in the clinical setting. However, ¹⁹F MRI signal at ultra-high-field (UHF) has poor detection sensitivity compared to other imaging modalities.

Goal(s): Nevertheless, its exact contribution to this process has not yet been investigated at 7T MRI with a large animal model.

Approach: To address this, we investigated ¹⁹F MRI on Phantoms and in a large animal model of AMI at UHF MRI.

Results: Our results suggest a TruFISP sequence and its rapid acquisition time as beneficial for ¹⁹F MRI signal detection in the targeted regions.

Impact: The present work represents an MRI approach to test time and intensity of ¹⁹F signal i (ex vivo &in vivo) in large animal after AMI.

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