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Abstract #3073

Visualization of brain water dynamics in the occipital lobe using 17O MRI: short- and long-term observations

Moyoko Tomiyasu1, Hiromi Sano1, Yoshitaka Bito2, Takashi Oono3, Hiroyuki Kameda2, Riwa Kishimoto1, Tokuhiko Omatsu1, Kohsuke Kudo2, and Takayuki Obata1
1National Institutes for Quantum Science and Technology, Chiba, Japan, 2Hokkaido University, Sapporo, Japan, 3Taiyo Nippon Sanso, Tokyo, Japan

Synopsis

Keywords: Non-Proton, Non-Proton, O-17 MRI, human, water dynamics

Motivation: To enable and investigate the observation of in vivo water dynamics and the timescales of water movement through 17O signal detection from enriched H217O using 17O-MRI with a clinical 3T MRI scanner.

Goal(s): Assessing the feasibility of 17O-MRI in the human brain using imaging protocols on a clinical 3T MRI scanner.

Approach: Female volunteer: Enriched H217O was administered after MRI began. Using 17O-MRI at 3T, both short-term dynamic changes and week-long variations in 17O signal intensity were observed in the occipital lobe.

Results: Dynamic and time course changes in 17O signal intensity were observed in the occipital lobe.

Impact: This study demonstrates the potential of 17O-MRI to monitor brain water dynamics in vivo, capturing both rapid blood flow changes and longer-term equilibration with interstitial fluids. Findings support 17O-MRI as a valuable tool for understanding brain water distribution over time.

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Keywords