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Abstract #3074

An efficient post-processing pipeline for improved phase-cycled 23Na Multi-Quantum Coherences MRI

Christian Licht1,2,3, Efe Ilicak1,2,4,5, Fernando Boada3, Valentin Jost1,2, Maxime Guye6, Frank G. Zoellner1,2, Lothar R. Schad1,2, and Stanislas Rapacchi6,7
1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannhein, Heidelberg University, Mannheim, Germany, 3Radiological Sciences Laboratory, School of Medicine, Stanford University, Stanford, CA, United States, 4Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 5C.J. Gorter MRI Center, Department of Radiology, Leiden University Medical Center, Leiden, Netherlands, 6CNRS, CRMBM, Aix-Marseille University, Marseille, France, 7CHUV, Univeristy of Lausanne, Lausanne, Switzerland

Synopsis

Keywords: Non-Proton, Non-Proton, X-nuclei, sodium, single-quantum imaging, triple-quantum imaging

Motivation: To develop an improved post-processing pipeline for robust phase-cycled Cartesian single (SQ) and triple quantum (TQ) sodium MRI of the in vivo human brain at 7T.

Goal(s): Enhanced denoising and SQ/TQ signal separation capabilities to allow for substantially improved sodium SQ and TQ imaging.

Approach: A k-space-based low-rank denoising technique exploiting structural redundancies is proposed. Additionally, enhanced signal separation of SQ and TQ via Dynamic Mode Decomposition (DMD) is presented.

Results: The low-rank denoising approach produced high-quality images across all echo times, allowing up to 4-fold reduction in acquisition time. Interestingly, DMD separated SQ and TQ signals even under corrupted RF phase-cycling conditions.

Impact: This pipeline’s algorithms provide the sodium MRI community with powerful tools for signal separation and denoising, enabling clearer, more reliable SQ and TQ images even in challenging conditions, expanding applicability to clinical and experimental settings.

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Abstract

Keywords