Abstract #3075

In-vivo sodium triple quantum (TQ) MR signal extraction using a single-pulse sequence with single quantum time efficiency at 3T

Valentin Jost^1,2, Christian Licht^1,2,3, Simon Reichert^1,2, Dominik Zehender^1,2, and Frank G. Zöllner^1,2,4

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ³Radiological Sciences Lab, School of Medicine, Stanford University, Stanford, CA, United States, ⁴Cooperative Core Facility Animal Scanner ZI, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Synopsis

Keywords: Non-Proton, Non-Proton, sodium, TQ imaging, MQC, radial

Motivation: Detection of sodium TQ coherences, requires multi-pulse sequences combined with phase-cycling to suppress unwanted coherences, leading to non-feasible acquisition times in clinical settings.

Goal(s): Development of a faster sodium TQ imaging method in the human brain at 3T.

Approach: A radial multi-echo sequence is used to sample the temporal evolution of the sodium signal decay. The integral over the FID is computed to extract the TQ signal.

Results: Acquisition of in-vivo 3D sodium TQ images with an apparent resolution of 6x6x6mm³ was achived within 30 minutes. Robustness of the method was demonstrated for simulation, phantom and in-vivo data against a state-of-the-art phase-cycling sequence.

Impact: The method is readily applicable to any sodium studies that leverage a multi-echo sodium sequence and offers therefore, the potential to investigate multi-quantum coherences, potentially providing richer tissue characterization than tissue sodium concentration (TSC) alone.

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