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Abstract #3076

Towards in vivo quantitative 19F MRI in the Spleen

Kian Tadjalli Mehr1, Felix Spreter1, Simon Reiss1, Johannes Fischer1, David Boll2, Ali Caglar Özen1, Constantin von zur Mühlen2, Alexander Maier2, and Michael Bock1
1Department of Radiology, University Medical Center Freiburg, Freiburg, Germany, 2Department of Cardiology, University Medical Center Freiburg, Freiburg, Germany

Synopsis

Keywords: Non-Proton, Non-Proton

Motivation: Perfluorocarbon emulsions can track immune cells activated after myocardial infarction. However, quantitative in vivo 19F MRI in large animals is challenging due to positional changes of organs.

Goal(s): Developing a method to obtain comparable 19F signals in pig’s spleens on multiple measurements over one week using a non-homogeneous receive coil.

Approach: The receive coil was tracked using 19F markers. A region in the spleen with equal position from the coils was chosen for the evaluation.

Results: Phantom experiments showed similar signal within the ROI. In vivo, a signal decay was measured for each animal with an average half-life in the spleen of 4.6d.

Impact: The presented method allows for quantification of 19F signal decay in non-static large animal organs. While it already works well on its own, it allows for future combination with a sensitivity map in the future.

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Keywords