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Abstract #3077

Improved quantification of skin sodium through rapid biexponential relaxation measurement and signal loss compensation

Gurparkash Singh1, Christian Beaulieu1,2, and Robert Stobbe1,2
1Biomedical Engineering, University of Alberta, Edmonton, AB, Canada, 2Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada

Synopsis

Keywords: Non-Proton, Relaxometry, sodium MRI, non-proton

Motivation: Sodium MRI detects abnormal skin sodium accumulation in many metabolic disorders, but current methods vastly underestimate actual sodium concentrations because of signal loss from rapid biexponential T2 relaxation.

Goal(s): To improve skin sodium concentration measurement accuracy through individual relaxation measurement and compensation.

Approach: A spin-3/2 simulation dictionary-based skin sodium relaxometry method including blood sodium contribution was used to compensate signal loss in high-resolution surface-coil images of healthy human calf.

Results: Relaxation compensated skin sodium concentration of ~81 mM is much higher than typically reported (~20 mM) and is similar to ~85mM from atomic absorption spectroscopy and skin density.

Impact: Previous MRI studies of skin vastly underestimate sodium concentration. Rapid biexponential T2 relaxation measurement enables signal loss compensation to correct skin sodium concentration values.

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