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Abstract #3078

Comparison Of Hyperpolarized 129Xe and 19F Perfluoropropane Multiple-Breath Washout MRI In Healthy and CF Pediatric Populations

Faiyza Shoaib Alam1,2, Brandon Zanette1, Felix Ratjen1,3, and Giles Santyr1,2
1Translational Medicine, Hospital for Sick Children, Toronto, ON, Canada, 2Medical Biophysics, University of Toronto, Toronto, ON, Canada, 3Division of Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada

Synopsis

Keywords: Non-Proton, Contrast Agents, Hyperpolarized MR; multiple-breath washout; pediatric; data acquisition; comparison

Motivation: Imaging gas washout from the lungs using MRI (MBW MRI) is a promising tool for tracking treatment/understanding physiology. However, benefits/drawbacks of using hyperpolarized xenon versus perfluoropropane (PFP) gas remains unclear.

Goal(s): To compare MBW PFP-MRI and MBW Xe-MRI for assessing regional ventilation dynamics in pediatric CF/healthy controls.

Approach: MBW Xe- and/or PFP-MRI were performed same-day for 4 CF, 10 healthy children. Fractional ventilation (FV), coefficient of variation (CoVFV) and gravitational gradient were compared.

Results: PFP yielded significantly lower FV, higher CoVFV compared to xenon in health. In disease, xenon yielded increased FV from health, while PFP had decreased FV in one preliminary participant.

Impact: This work demonstrates how choice of contrast gas can influence MBW MRI. Understanding differences between MBW PFP- and Xe-MRI is important as PFP gains interest due to lower costs and improved clinical translatability for monitoring treatment progress compared to xenon.

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