Keywords: Non-Proton, Metabolism, MR Fingerprinting, Creatine Kinase, functional imaging, 31P
Motivation: The creatine kinase (CK) reaction rate is essential for understanding brain function. More importantly CK rates have been shown to change in various neurological conditions, including psychiatric disorders.
Goal(s): In this abstract a novel functional imaging modality is introduced called functional Creatine Kinase Imaging (fCKI).
Approach: Participants are exposed to a visual paradigm during CKI acquisition.
Results: fCKI reveals a 15% increase in CK enzyme reaction rate in the occipital lobe, consistent with prior findings. Additionally, fCKI provides, for the first time, a 3D activation map, with activation clusters predominantly located in the visual cortex.
Impact: A novel functional modality, functional Creatine Kinase Imaging (fCKI) is introduced. fCKI reveals increased CK enzyme activity in the occipital lobe and, for the first time, a 3D activation-map, with activation clusters predominantly found in the visual cortex.
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