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Abstract #3079

Functional Creatine Kinase Imaging (fCKI) for brain functional and metabolic imaging

Mark Widmaier1,2,3, Antonia Kaiser1,3, Daniel Wenz1,3, Ying Xiao1,3, Song-I Lim1,3, Yun Jiang4, and Lijing Xin1,3,5
1Animal Imaging and Technology, EPFL, Lausanne, Switzerland, 2Laboratory of functional and metabolic imaging, EPFL, Lausanne, Switzerland, 3Center for Biomedical Imaging (CIBM), Lausanne, Switzerland, 4Radiology, University of Michigan, Ann Arbor, MI, United States, 5Institute of Physics, EPFL, Lausanne, Switzerland

Synopsis

Keywords: Non-Proton, Metabolism, MR Fingerprinting, Creatine Kinase, functional imaging, 31P

Motivation: The creatine kinase (CK) reaction rate is essential for understanding brain function. More importantly CK rates have been shown to change in various neurological conditions, including psychiatric disorders.

Goal(s): In this abstract a novel functional imaging modality is introduced called functional Creatine Kinase Imaging (fCKI).

Approach: Participants are exposed to a visual paradigm during CKI acquisition.

Results: fCKI reveals a 15% increase in CK enzyme reaction rate in the occipital lobe, consistent with prior findings. Additionally, fCKI provides, for the first time, a 3D activation map, with activation clusters predominantly located in the visual cortex.

Impact: A novel functional modality, functional Creatine Kinase Imaging (fCKI) is introduced. fCKI reveals increased CK enzyme activity in the occipital lobe and, for the first time, a 3D activation-map, with activation clusters predominantly found in the visual cortex.

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Keywords