Meeting Banner
Abstract #3086

Deuterium magnetic resonance imaging of tumors after in vivo deuterated water labeling to low total body water levels.

Mingchen He1,2, Jill M Duzen1,2, Hellmut Merkle3, Joseph A Spernyak4, Terri L Larus5, Donald E Farthing5, and Nataliya Prokopenko Buxbaum1,2,6
1Division of Pediatric Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States, 2Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States, 3National Institutes of Health, National Institute of Neurological Disoders and Stroke, Bethesda, MD, United States, 4Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States, 5National Cancer Institute, National Institutes of Health, Bethesda, MD, United States, 6Department of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States

Synopsis

Keywords: Deuterium, Cancer, molecular imaging; preclinical

Motivation: Systemic deuterated water administration leads to higher cellular deuterium content and imaging contrast between proliferating tumor and healthy tissue.

Goal(s): We previously showed excellent deuterium imaging contrast between xenografts and muscle at 9.4T with 7 days of 8% deuterated water in total body water (TBW), v/v. Clinical translation of this approach would benefit from lower TBW goals given volume, cost, and ease.

Approach: We tested lower TBW deuterium levels and shorter duration of labeling in a xenograft model at 7T.

Results: We demonstrate deuterium imaging contrast between tumors and muscle at 2 and 4% TBW without significant benefit from longer duration of labeling.

Impact: Systemic administration of deuterated water can preferentially label tumors for dMRI. This approach has been tested in animal models, while clinical implementation in oncology warrants lower doses and shorter labeling durations. Thus, we tested clinically relevant deuterated water labeling schemas.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords