Abstract #3115

Bone Marrow Proton Density Fat Fraction Measurement Using Flip-Angle Modulated Chemical Shift-Encoded MRI

Raphael do Vale Souza¹, Alexandra Anagnostopoulos¹, Jiayi Tang^1,2, Daiki Tamada¹, Julius Frederik Heidenreich^1,3, Scott B Reeder^1,2,4,5,6, Diego Hernando^1,2, and Ali Pirasteh¹

¹Department of Radiology, University of Wisconsin-Madison, Madison, WI, United States, ²Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ³Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, ⁴Department of Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁵Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Bone/Skeletal, biomarkers

Motivation: Non-invasive measurement of bone marrow fat content, which helps characterize and monitor hematologic disease processes, is a major unmet need. Chemical-shift-encoded (CSE) MRI with 2D flip-angle modulation (FAM) offers a motion-robust alternative to 3D-CSE MRI for PDFF measurement.

Goal(s): To compare bone marrow PDFF measured using FAM-CSE and 3D-CSE MRI.

Approach: Single-center retrospective study of patients who underwent both FAM-CSE and 3D-CSE MRI; vertebral body PDFF measured using both techniques were compared for linearity and bias.

Results: Bone marrow PDFF measured using FAM-CSE and 3D-CSE MRI demonstrate strong linearity, but also non-negligible relative bias compared to each other.

Impact: FAM-based CSE MRI is a promising tool for motion-robust measurement of bone marrow PDFF, which may help characterization of many hematologic disease processes. However, it requires further validation and addressing potential sources of bias.

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