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Abstract #3119

Quantitative MRI Techniques to Monitor Changes in Osteonecrosis of the Femoral Head Following Core Decompression: A Preliminary Study

Erick O. Buko1,2, Edward Y. Cheng3, Jutta M. Ellermann2,4, and Casey P. Johnson1,2
1Department of Veterinary Clinical Sciences, University of Minnesota, Saint Paul, MN, United States, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3Department of Orthopedic Surgery, University of Minnesota, Minneapolis, MN, United States, 4Department of Radiology, University of Minnesota, Minneapolis, MN, United States

Synopsis

Keywords: Osteoarthritis, Osteoarthritis

Motivation: T1- and T2-weighted MRI fails to detect post-treatment healing of osteonecrosis of the femoral head (ONFH), limiting further treatment.

Goal(s): To determine whether quantitative T2, fat fraction (FF), and diffusion (D) mappings can detect changes in ONFH lesions following core decompression treatment.

Approach: Patients with ONFH were imaged at 3T MRI before (n=10) and 6 months after (n=7) core decompression. Pre-operatively, T2, FF, and D values from affected vs. surrounding unaffected regions of the hips were compared, and their changes in affected areas were evaluated post-operatively.

Results: T2, FF, and D are sensitive in detecting ONFH and subsequent compositional changes following core decompression.

Impact: Quantitative MRI techniques are sensitive in detecting compositional changes in ONFH lesions following core decompression treatment. These methods may help identify patients who can benefit from a second intervention and help improve patient management and optimize therapeutic approaches for ONFH.

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