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Abstract #3120

Exploring Lumbar Intervertebral Disc Degeneration via 23Na-MRI: A Clinical Study

Yuta Nakahashi1,2, Tsukasa Saida3, Miki Yoshida1,2, Masashi Shindo4, Koji Yamada4, Takao Ishimori4, Masataka Terakado1, Toshitaka Ishiguro3, Jihun Kwon5, and Takahito Nakajima3
1Department of Diagnostic and Interventional Radiology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan, 2Department of Radiology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan, 3Department of Radiology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, 4Department of Radiology, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan, 5MR Clinical Science, Philips Japan, Ltd., Tokyo, Japan

Synopsis

Keywords: Other Musculoskeletal, Non-Proton, disc degeneration, sodium, multinuclear

Motivation: Intervertebral disc degeneration (IDD) significantly contributes to chronic low back pain, yet traditional imaging techniques are limited in their ability to provide quantitative assessments.

Goal(s): This study aimed to evaluate the clinical applicability of 23Na-MRI in assessing sodium concentration as a biomarker for disc degeneration.

Approach: 23Na signal intensities were compared with T2-weighted images and the Pfirrmann classification in 90 intervertebral discs of 30 patients.

Results: 23Na-MRI demonstrated significant correlations with T2 ratios, disc thickness, and degeneration grades, proving its effectiveness for quantifying IDD progression.

Impact: 23Na-MRI offers a non-invasive method to quantitatively assess intervertebral disc degeneration, complementing traditional techniques. Its strong correlation with disc degeneration indicators supports its clinical relevance, potentially improving diagnosis and treatment for patients with chronic low back pain.

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Keywords