Abstract #3124

Can Texture Features of T2WI Capture the Effectiveness of Gel Implantation Treatment for Intervertebral Disc Degeneration?

Maho Kitagawa¹, Mui Saito¹, Katsuhisa Yamada², Hideki Sudo², and Khin Khin Tha^1,3

¹Department of Biomarker Imaging Science, Graduate School of Biomedical Science and Engineering, Hokkaido University, Sapporo, Japan, ²Department of Orthopedic Surgery, Hokkaido University Faculty of Medicine, Sapporo, Japan, ³Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan

Synopsis

Keywords: Other Musculoskeletal, Body, Intervertebral disc degeneration, T2WI, texture analysis, Gel implantation

Motivation: Lumbar intervertebral disc (IVD) degeneration is an important health problem. However, conventional treatments for IVD degeneration do not solve the underlying cause of the degeneration.

Goal(s): To compare the quantitative T2WI features of IVD in the conventional treatment group and the gel-implantation therapy group, a new treatment that may be effective in repairing IVD tissue.

Approach: Histogram and texture features were calculated from lesion IVD in T2WI and compared in relation to group and time.

Results: Contrast, a measure of local heterogeneity, was significantly higher in the gel group than in the conventional treatment group.

Impact: Our results indicate that IVD degeneration may be inhibited and IVD tissue is preserved in the gel group. Texture features, which provide information on the spatial distribution of pixels, could evaluate the efficacy of new treatments for IVD degeneration.

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