Keywords: Dementia, Aging, Fat & Fat/Water Separation;Bone
Motivation: Whether quantitative bone marrow fat scores are associated with cognitive function.
Goal(s): To determine the correlation between cognitive function and skull and vertebral bone marrow fat fraction.
Approach: Applying the mDIXON-Quant technique to assess bone marrow fat fraction in the cranial and lumbar vertebrae, and examining its correlation with cognitive impairment.
Results: A negative correlation is observed between the fat fraction of the cranial and vertebral bones and the Mini-Mental State Examination (MMSE) scores.
Impact: The quantitative fat fraction of bone marrow in the cranium and vertebrae is associated with cognitive impairment.，This may provide a signature research direction for the bone-brain axis.
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