Abstract #3140

Elevated regional cerebral oxygen extraction fraction was associated with worse cognitive performance in older adults with vascular risks

Jie Song¹, Wen Shi¹, Julia Suconic², Kaisha Hazel², George Pottanat², Ebony Jones², Cuimei Xu², Kumiko Oishi², Yifan Gou¹, Paul Rosenberg³, Rita Kalyani⁴, Abhay Moghekar⁵, Sevil Yasar⁶, Doris Lin², Marilyn Albert⁵, Hanzhang Lu², and Dengrong Jiang²

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Division of Geriatric Psychiatry and Neuropsychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁶Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Dementia, Dementia, Small vessel disease, Vascular dementia

Motivation: Cognitive impairment from vascular disease lacks clear biomarkers, complicating early detection. Brain oxygen-extraction-fraction (OEF), an indicator of oxygen utilization, may reveal vascular contributions to cognitive decline, especially in executive function.

Goal(s): We aimed at investigating the relationship between cortical and subcortical OEF and cognitive function in individuals with vascular risk.

Approach: We used advanced MRI techniques (aTRUPC) to measure cortical and subcortical OEF in older adults (N=87) with vascular risks, assessing its association with global and domain cognitive performance and vascular-risk-scores.

Results: Elevated cortical and subcortical OEF were significantly related to poorer global cognition and executive function, meanwhile significantly correlated with higher vascular-risk-scores.

Impact: This research suggests that OEF may serve as an early biomarker for cognitive impairment due to vascular disease, particularly impacting executive function, which could improve early intervention strategies and monitoring of vascular cognitive impairment.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.