Keywords: Neurofluids, Aging, Subarachnoid space, Fractional anisotropy, high b-value
Motivation: A recent study reported an age-related decline in diffusion anisotropy in subarachnoid space, where the diffusion MRI was measured using a conventional b-value of 1000. Using higher b-values may help identify contributions of the tissue microstructure in subarachnoid space to aging.
Goal(s): We aimed to investigate age-related changes in diffusion anisotropy within subarachnoid space using higher b-values.
Approach: We measured diffusion parameters using higher b-values (1000, 2000, and 3000) and observed their associations with age.
Results: Using higher b-values, we observed stronger associations between subarachnoid space diffusion anisotropy and age, with higher correlation coefficients and lower p-values.
Impact: The age-related decline in diffusion anisotropy of subarachnoid space was stronger using higher b-values. This suggests that age-related decline in diffusion anisotropy may be influenced by the tissue microstructure in subarachnoid space.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords