Meeting Banner
Abstract #3152

Cognitive Impairment and Amygdala Subregion Volumes in Elderly with Cerebral Small Vessel Disease: A Prospective Cohort Study

Zhenyu Cheng1, Linfeng Yang2, Jing Li3, Yiwen Chen4, Liang Pengcheng4, Wang Yuanyuan5, Na Wang6, Xinyue Zhang6, Changhu Liang6, Meng Li7, and Lingfei Guo6
1Binzhou Medical University, YAN TAI, China, 2Jinan Maternity and Child Care Hospital affiliated to Shandong First Medical University, Jinan, China, 3Department of Radiology, Beijing Tsinghua Changgung Hospital, Bei jing, China, 4Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji nan, China, 5Binzhou Medical University, Yantai, China, 6Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, 7Jena University Hospital, Jena, Germany

Synopsis

Keywords: Other Neurodegeneration, Stroke

Motivation: This study was motivated by the need to understand the association between volume changes in specific amygdala subregions and cognitive impairment in patients with CSVD.

Goal(s): The primary goal is to examine the relationship between amygdala subregion volumes and cognitive function in CSVD patients, aiming to identify specific atrophic patterns and their contributions to cognitive decline.

Approach: A prospective cohort study included 114 CSVD patients and 129 healthy controls.

Results: The study found significant atrophy in the left cortical nucleus among CSVD patients, with this atrophy correlating negatively with performance on cognitive tasks related to attention, memory, and executive function.

Impact: These findings suggest that amygdala subregion atrophy, particularly in the left cortical nucleus, may serve as an early biomarker for cognitive impairment in CSVD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords