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Abstract #3153

Quantitative MRI Correlates of Brain Non-heme Iron

Yu Veronica Sui1, Zakia Ben Youss1, Ryn Flaherty1, Gayatri Maria Schur1, Jingjia Chen1, Pippa Storey1, and Mariana Lazar1
1Department of Radiology, New York University Grossman School of Medicine, New York, NY, United States

Synopsis

Keywords: Other Neurodegeneration, biomarkers, brain iron

Motivation: Multiple quantitative MR (qMR) metrics have been shown to be sensitive to brain iron. However, direct comparisons among these metrics and with histological iron data are limited.

Goal(s): We aim to evaluate the effective (R2*) and irreversible (R2) transverse relaxation rates as well as quantitative susceptibility mapping (QSM) in quantifying non-heme brain iron levels.

Approach: We tested associations among qMR metrics and iron content estimated from histologically determined trajectories of iron accumulation in healthy young individuals.

Results: While all metrics showed sensitivity to iron content, R2* is more robust in its association with histological estimates of iron from literature.

Impact: This study examined MRI-based measures of non-heme brain iron, providing valuable insights into their reliability as iron markers across brain tissue types and their correspondence with histology.

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