Abstract #3154

Blunted Hyperemia and Compromised Oxygen Delivery in Iron Deficiency Anemia

Clio González-Zacarías^1,2, Emma Carpenter^2,3, Samantha Mejia², Hannah Salcudean², Botian Xu^2,4, Silvie Suriany², Sneha Verma², Anand A. Joshi¹, Peter Chiarelli^5,6, Richard Leahy¹, and John Wood^2,7

¹Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, ²Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ³Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, United States, ⁴Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ⁵Pediatric Neurosurgery, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁶Clinical Neurological Surgery, Keck School of Medicine of USC, Los Angeles, CA, United States, ⁷Pediatrics and Radiology, Keck School of Medicine of USC, Los Angeles, CA, United States

Synopsis

Keywords: Other Neurodegeneration, Arterial spin labelling, Iron deficiency anemia, gray matter, white matter, cerebral blood flow. arterial transit time, oxygen delivery, iron, hypoxia

Motivation: The impaired oxygen-carrying capacity of blood in iron deficiency anemia (IDA) may contribute to cognitive deficits in adult women.

Goal(s): To determine whether global and regional brain oxygen delivery is affected in women with IDA.

Approach: We quantified cerebral blood flow (CBF), arterial transit time (ATT) and oxygen delivery (O2Del) in 23 IDA adult women and 21 matched control subjects using pseudo-continuous time-encoded arterial spin labeling (pCASL).

Results: IDA exhibits slightly increased CBF and decreased ATT compared to controls. O2Del was significantly decreased globally in cortical and white matter regions.

Impact: These data suggest that physiological compensation to compromised hemoglobin and erythrocyte production in IDA is insufficient to maintain cerebral oxygen delivery. Time-encoded pCASL may provide a biomarker to indicate the necessity for medical intervention.

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