Keywords: Other Neurodegeneration, Neurodegeneration
Motivation: Cognitive dysfunction significantly impacts outcomes in schizophrenia, the relationship between brain structural changes and specific cognitive domains remains unclear. Understanding these relationships could provide objective biomarkers for disease progression.
Goal(s): To identify associations between brain structural changes and cognitive domains in schizophrenia and investigate distinct patterns of disease progression using neuroimaging.
Approach: Surface-based morphometry was performed on MRI data from schizophrenia patients and healthy controls. Disease progression patterns were analyzed using the SuStaIn algorithm.
Results: Specific brain regions correlated with distinct cognitive domains. Two progression patterns were identified: one showing widespread cortical changes and another initiating in basal ganglia, representing different disease stages.
Impact: The identification of stage-specific brain changes and their relationship to cognitive function provides a framework for objective disease monitoring and suggests potential targets for stage-specific therapeutic interventions in schizophrenia.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords