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Abstract #3156

Amide proton transfer magnetic resonance imaging to assess protein metabolism in the brain of patients with T2DM and association with cognition

Hongjun Jiang1, Shuncheng Yu1, Langxuan Yu1, and weiwei wang1
1Radiology department, The first affiliated hospital of Dalian medical university, Dalian City, China

Synopsis

Keywords: Other Neurodegeneration, Diabetes

Motivation: The prevalence of type 2 diabetes is growing rapidly worldwide. As the disease progresses, concomitant cognitive impairment is also a major problem in type 2 diabetes today.

Goal(s): Finding metabolic alterations in the diabetic brain that are predictive of diabetes associated with cognition using imaging is the aim of our research endeavors.

Approach: We have studied type 2 diabetes through amide proton transfer magnetic resonance imaging(APT-MRI). The cognitive correlation was explored by dividing it into three groups.

Results: Our results show that APT imaging can reflect the metabolic status in the brain and predict the degree of cognitive function in patients with T2DM.

Impact: This study demonstrates the value of APT imaging technology applied to type 2 diabetes and provides a new imaging method for assessing cognitive function in patients with type 2 diabetes, which is beneficial for clinicians to better monitor the condition.

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