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Abstract #3158

Can nigrosome 1 assessment via susceptibility map-weighted imaging (SMwI) predict presynaptic DAT PET results in RBD patients?

Beomseok Sohn1, Eung Yeop Kim1, and Eun Yeon Joo2
1Department of Radiology, Samsung Medical Center, Seoul, Korea, Republic of, 2Department of Neurology, Samsung Medical Center, Seoul, Korea, Republic of

Synopsis

Keywords: Other Neurodegeneration, Neurodegeneration

Motivation: RBD is a prodromal symptom of Parkinson's disease, and DAT-PET aids in diagnosis. However, its accessibility is limited, and SMwI has not been studied as a screening tool.

Goal(s): This study aims to evaluate how accurately SMwI predicts presynaptic dopaminergic function in RBD patients, addressing a critical gap in current research.

Approach: A review of RBD patients diagnosed by polysomnography was conducted, with all undergoing MRI, DAT-PET, and SMwI comparison analysis

Results: In 64 patients, DAT-PET showed decreased uptake in 56.3%, with SMwI missing 15.6% of these. SMwI detected abnormalities in 6.3% not found by DAT-PET, with 72.2% sensitivity and 85.7% specificity.

Impact: In RBD patients, nigrosome 1 evaluation using SMwI showed moderate agreement with DAT PET. However, SMwI's diagnostic sensitivity was lower than in Parkinson’s disease, indicating it may not sufficiently replace DAT PET in RBD diagnosis.

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