Abstract #3159

The relationship between cognitive impairment and changes in cortical thickness and surface area of brain regions in patients with preeclampsia

Yuanyuan Wang^1,2, Meng li³, Xinyue Zhang⁴, Na Wang⁵, Linfeng Yang⁶, Tao chen⁷, and Lingfei Guo⁸

¹School of Medical Imaging, Binzhou medical university, Yantai, China, ²Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ³Department of Psychiatry and Psychotherapy, Jena University Hospital, Germany, Jena, Germany, ⁴Shandong Provincial Hospital affiliated Shandong First Medical University, Jinan, China, ⁵Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁶Department of Radiology, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China, ⁷Department of Clinical laboratory, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, jinan, China, ⁸Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

Synopsis

Keywords: Other Neurodegeneration, Neurodegeneration

Motivation: Hypoxia in preeclampsia can lead to structural damage of gray matter and white matter, and preeclampsia is associated with cognitive decline and brain atrophy.

Goal(s): The objective of this study was to compare cortical thickness and surface area of each brain region of patients with preeclampsia a (PE)nd healthy-term controls to explore the causative factors of cognitive impairment in PE patients.

Approach: Preprocessing of structural and functional MRI data was performed to obtain the cortical thickness and surface area.

Results: Cognitive decline in PE patients is mainly associated with changes in the cortical surface area of R-superior frontal and L-pars opercularis.

Impact: The thickness of R-superior frontal is a signal of cognitive impairment in patients, which provides appropriate intervention timing and targets for clinical practice. The thickness of L-pars opercularis mediates the effects of pre-pregnancy BMI and MAP on cognitive impairment.

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