Abstract #3160

Study on the Mechanism of Cognitive Impairment in NMOSD Patients Mediated by the Reorganization of FC Related to Iron Metabolism Abnormalities

Xi Li¹, Bing Liu¹, Fuyan Li¹, Longji Xu^1,2, Xiaoxia Lin^1,2,3, Jing Wang¹, Yuxi Liu¹, Wenjing Zhang¹, Liangjie Lin⁴, Fuxin Ren¹, and Fei Gao¹

¹Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ²Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China, ³Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan, China, ⁴Clinical and Technical Support, Philips Healthcare, Beijing, China

Synopsis

Keywords: Other Neurodegeneration, fMRI (resting state), QSM

Motivation: The mechanisms of cognitive impairment in NMOSD patients are not yet clear.

Goal(s): To investigate how abnormal iron metabolism reorganizes functional connectivity networks and correlates with cognitive impairment using combined QSM and rs fMRI.

Approach: Participants underwent QSM imaging to assess DGM iron concentration and rs fMRI for brain network analysis.

Results: Higher iron concentration in GPe may affect its communication with the right precentral gyrus and is associated with cognitive impairment in NMOSD patients.

Impact: This study provides a new perspective on elucidating the neural mechanisms of cognitive impairment in NMOSD patients through the combined use of QSM and rs fMRI techniques.

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