Abstract #3161

Transient Global Amnesia: Multi-timepoint 3T and 7T MRI Analysis of Acute Hippocampal Lesions - A One-year Longitudinal Prospective Study

Barbara Daria Wichtmann^1,2, Zeynep Bendella¹, Mónica Ferreira², Martin Reuter^2,3, Christine Kindler^2,4, Theodor Rüber^2,5, Alexander Radbruch^1,2, Gabor C. Petzold^2,6, Daniel Paech^1,3, Tony Stöcker², Felix Jürgen Bode^2,6, and Niklas Michael von Danwitz^2,6

¹Department of Neuroradiology, University Hospital Bonn, Bonn, Germany, ²German Center for Neurodegenerative Diseases, Bonn, Germany, ³Department of Radiology, Mass General Brigham, Boston, MA, United States, ⁴Department of Neurology, University Hospital Bonn, Bonn, Germany, ⁵Department of Epileptology, University Hospital Bonn, Bonn, Germany, ⁶Department of Vascular Neurology, Center of Neurology, University Hospital Bonn, Bonn, Germany

Synopsis

Keywords: Other Neurodegeneration, Neuro, High-Field MRI, Transient Global Amnesia

Motivation: Transient global amnesia (TGA) presents with temporary DWI-visible hippocampal lesions. The long-term implications of these lesions remain unclear, particularly whether they cause permanent structural changes.

Goal(s): To evaluate whether acute TGA-associated hippocampal lesions lead to permanent structural changes detectable with state-of-the-art neuroimaging.

Approach: 18TGA patients underwent same-day comparative 3T and 7T MRI scanning at three timepoints over one year (24-72h, 1 month, 12 months post-event), utilizing high-resolution morphological and diffusion-weighted imaging.

Results: Initial DWI-hyperintense lesions were detected in 16/18 patients, but no residual signal changes or structural abnormalities were observed at either field strength during follow-up examinations, suggesting complete resolution without permanent damage.

Impact: Leveraging ultra-high field MRI, this study provides evidence for clinicians and patients that acute hippocampal lesions in TGA do not result in chronic structural changes. The comprehensive multi-timepoint imaging protocol establishes a methodological framework for future investigations into TGA pathophysiology.

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