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Abstract #3207

Prospective Motion Correction of Arterial Spin Labelling Demonstrated with Patient-Informed Motion

Ulrich Lindberg1, Malte Laustsen2, Thomas Ulrich3, Alba Castrillo Perote2, Gérard Crelier3, Henrik Bo Wiberg Larsson1, and Thomas Gaass2
1Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark, 2TracInnovations A/S, Ballerup, Denmark, 3Gyrotools LLC, Zurich, Switzerland

Synopsis

Keywords: Motion Correction, Motion Correction

Motivation: Arterial Spin Labelling is a promising non-invasive technique for cerebral perfusion measurement, but its sensitivity to patient motion limits its clinical application. This research explores prospective motion correction (PMC) to enhance ASL’s reliability in motion-prone patient groups.

Goal(s): To evaluate whether PMC using the Tracoline device improves the quality of Perfusion Weighted Imaging (PWI) in ASL scans affected by motion.

Approach: ASL scans were conducted with PMC enabled, using head motion data from Tracoline to adjust the scan geometry in real-time during image acquisition.

Results: PMC significantly reduced motion artefacts, improving PWI quality and similarity to ground truth scans without motion.

Impact: This study demonstrates that prospective motion correction significantly enhances ASL image quality, making it more clinically viable for motion-prone patients. The findings encourage further exploration of real-time correction methods, potentially expanding ASL’s diagnostic applicability across diverse patient groups.

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Keywords