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Abstract #3214

QSM source separation Reveals Iron Deposition in cerebral small vessel disease

Mengmeng Feng1, Xiaoyi Liu1, Senhao Zhang1, Boyan Xu2, and Jie Lu1
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Image Reconstruction, Neurodegeneration

Motivation: Abnormal iron and myelin distributions are associated with neurodegenerative diseases. QSM source separation, an advanced technique, can effectively distinguish paramagnetic iron and diamagnetic myelin contributions.

Goal(s): To compare susceptibility values in deep nuclei between CSVD patients and healthy controls and disentangle paramagnetic iron and diamagnetic myelin contributions.

Approach: Obtain total, positive and negative susceptibility values based on QSM source separation to assess iron deposition in deep nuclei in CSVD.

Results: Higher positive susceptibility values observed in bilateral caudate, putamen, pallidum, accumbens, substantia nigra pars compacta, substantia nigra pars reticulata, and red nucleus in CSVD patients.

Impact: In this study, we used QSM source separation to distinguish paramagnetic iron and diamagnetic myelin contributions, providing a strong theoretical basis and accuracy support for the existence of the phenomenon of iron deposition in deep nuclei in CSVD patients.

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