Keywords: Image Reconstruction, Neurodegeneration
Motivation: Abnormal iron and myelin distributions are associated with neurodegenerative diseases. QSM source separation, an advanced technique, can effectively distinguish paramagnetic iron and diamagnetic myelin contributions.
Goal(s): To compare susceptibility values in deep nuclei between CSVD patients and healthy controls and disentangle paramagnetic iron and diamagnetic myelin contributions.
Approach: Obtain total, positive and negative susceptibility values based on QSM source separation to assess iron deposition in deep nuclei in CSVD.
Results: Higher positive susceptibility values observed in bilateral caudate, putamen, pallidum, accumbens, substantia nigra pars compacta, substantia nigra pars reticulata, and red nucleus in CSVD patients.
Impact: In this study, we used QSM source separation to distinguish paramagnetic iron and diamagnetic myelin contributions, providing a strong theoretical basis and accuracy support for the existence of the phenomenon of iron deposition in deep nuclei in CSVD patients.
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