Abstract #3215

Bipolar Readouts Improve Quantitative Performance of Motion-Robust, Flip-Angle Modulated PDFF and R2* Mapping at High R2*

Jiayi Tang^1,2, Daiki Tamada², Jitka Starekova², Alexandra A Anagnostopoulos², Austin Murphy², Norah Duritsa², Garrett Fullerton^1,2, James Hao Wang^1,2, Alan McMillan^1,2,3,4,5, Aaron Carrel⁶, Ivan Rosado Mendez^1,2, Scott B Reeder^1,2,3,7,8, and Diego Hernando^1,2

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁴Data Science Institute, University of Wisconsin-Madison, Madison, WI, United States, ⁵Electrical and Computer Engineering, University of Wisconsin-Madison, Madison, WI, United States, ⁶Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, ⁷Medicine, University of Wisconsin-Madison, Madison, WI, United States, ⁸Emergency Medicine, University of Wisconsin-Madison, Madison, WI, United States

Synopsis

Keywords: Pulse Sequence Design, Fat and Fat/Water Separation, iron quantification

Motivation: Flip-angle modulation (FAM) for motion-robust fat and iron quantification has been previously proposed with monopolar readouts, but may have poor performance in high R2* patients. Implementing bipolar readouts may shorten scan times and improve performance.

Goal(s): Development of bipolar-FAM and evaluation in patients with liver steatosis and/or iron overload. Evaluation of breath-held bipolar-FAM, which remains artifact free in failed breath-holds.

Approach: Prospective phantom and in vivo studies in adult liver steatosis/iron overload patients, and children with normal and elevated BMI.

Results: Free-breathing and breath-held bipolar-FAM both show reduced bias and artifacts and improved repeatability in the R2*=300-500s^-1range.

Impact: Bipolar-FAM may facilitate free-breathing FAM-based fat and iron quantification in patients with elevated R2*. The faster bipolar readouts improve motion robustness and enable breath-held FAM, which provides consistently-registered slices with good breath-holds, and remains motion-artifact free with poor breath-holds.

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