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Abstract #3257

Voxelwise T2 Corrected Multi-TE ASL in Meningiomas: Initial Experience

Ayse Irem Cetin1, Gulce Turhan1, Amnah Mahroo2, Beatriz E. Padrela3, Simon Konstandin2, Daniel Christopher Hoinkiss2, Nora-Josefin Breutigam2, Vera Keil3, Ayca Ersen-Danyeli4,5, Koray Özduman5,6, Klaus Eickel2,7, Henk Mutsaerts3,8,9, Matthias Günther2,10,11, Alp Dincer5,12,13, Jan Petr14, and Esin Ozturk-Isik1,5
1Biomedical Engineering, Bogazici University, Istanbul, Turkey, 2Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany, 3Amsterdam University Medical Center, Amsterdam, Netherlands, 4Department of Pathology, Acibadem University, Istanbul, Turkey, 5Brain Tumor Research Group, Acibadem University, Istanbul, Turkey, 6Department of Neurosurgery, Acibadem University, Istanbul, Turkey, 7Bremerhaven University of Applied Sciences, Bremerhaven, Germany, 8Amsterdam Neuroscience, Brain Imaging, Amsterdam, Netherlands, 9Radiology and Nuclear Medicine, Vrije Universiteit, Amsterdam, Netherlands, 10mediri GmbH, Heidelberg, Germany, 11University of Bremen, Bremen, Germany, 12Department of Radiology, Acibadem University, Istanbul, Turkey, 13Neuroradigical Applications and Research Center, Istanbul, Turkey, 14Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany

Synopsis

Keywords: Data Processing, Arterial spin labelling

Motivation: The multi-TE ASL method could assess tumor permeability in meningiomas. Standard quantification of multi-TE ASL requires a global transverse relaxation time (T2) value, which might lead to suboptimal perfusion estimations at tumor region.

Goal(s): To evaluate tumor permeability in meningiomas using multi-TE ASL with voxelwise T2 estimates.

Approach: Multi-TE ASL data were acquired in six meningioma patients. Mono-exponentially fitted T2 maps were used in the multi-TE ASL data processing to estimate water exchange (Tex) and perfusion (CBF) maps using ExploreASL.

Results: Lower Tex in the tumor region and normal-appearing gray matter (NAGM) and higher Tex in the normal-appearing white matter (NAWM) were observed.

Impact: This study demonstrated that multi-TE ASL incorporating voxelwise T2 values can measure CBF and Tex in meningiomas to assess tumor permeability.

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Abstract

Keywords