Abstract #3275

Phase-based Electrical Conductivity as a Potential Imaging Marker of Treatment Effectiveness in Lumbar Intervertebral Disc Herniation

Khin Khin Tha¹, Maho Kitagawa², Mui Saito³, Peiyao Song³, Katsuhisa Yamada⁴, Hideki Sudo⁴, and Ulrich Katscher⁵

¹Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Sapporo, Japan, ²Laboratory for Biomarker Imaging Science, Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, ³Hokkaido University Graduate School of Biomedical Science and Engineering, Sapporo, Japan, ⁴Hokkaido University Faculty of Medicine, Sapporo, Japan, ⁵Philips GmbH Innovative Technologies, Hamburg, Germany

Synopsis

Keywords: Electromagnetic Tissue Properties, Degenerative, intervertebral disc, lumbar, degeneration

Motivation: Electrical conductivity (σ) of intervertebral disc (IVD) may show biological and structural changes associated with ultra-purified alginate (UPAL) gel implantation treatment for lumbar IVD degeneration.

Goal(s): This study compared σ of lumbar IVD derived from electric properties tomography (EPT) between patients receiving standard discectomy and those receiving UPAL gel implantation.

Approach: The major σ histogram metrics of each IVD were extracted and compared between the two treatment groups.

Results: The minimum σ (σ_min) significantly decreased following standard discectomy suggesting advancing degeneration. In contrast, the σ histogram metrics of the gel implantation group did not vary, suggesting its superiority over the standard discectomy.

Impact: This is the first study which evaluated treatment effectiveness of surgery (standard discectomy and UPAL gel implantation) in lumbar IVD degeneration using a recently developed noninvasive quantitative MRI index, i.e., σ of IVD.

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