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Abstract #3276

Unraveling the Hidden Link: Electrical Conductivity-Apparent Diffusion Coefficient Correlation Patterns in Thoracic Lesions

Jincheng Wang1, Ulrich Katscher2, Eiki Kikuchi3, Maho Kitagawa1, Yasuka Kikuchi4, Yuki Yoshino4, Peiyao Song1, and Khin Khin Tha1,5
1Laboratory for Biomarker Imaging Science, Hokkaido University Graduate School of Medical Science and Engineering, Sapporo, Japan, 2Philips GmbH Innovative Technologies, Hamburg, Germany, 3Department of Respiratory Medicine, Hokkaido University Faculty of Medicine, Sapporo, Japan, 4Department of Diagnostic Imaging, Hokkaido University Faculty of Medicine, Sapporo, Japan, 5Global Center for Biomedical Science and Engineering, Hokkaido University Faculty of Medicine, Sapporo, Japan

Synopsis

Keywords: Electromagnetic Tissue Properties, Electromagnetic Tissue Properties, thoracic, apparent diffusion coefficient

Motivation: There have been discrepancies about correlation between electrical conductivity (σ) and apparent diffusion coefficient (ADC) of tissues. A better understanding of the σ-ADC relationship and the impact of tissue heterogeneity on this correlation could provide valuable insights into the underlying microstructural differences.

Goal(s): To explore the factors underlying the relationship between σ and ADC, this study aimed to investigate this σ-ADC relationship across thoracic lesion types.

Approach: σ-ADC relationships were assessed across lesion categories: entire cohort, solid lesions, malignancies, histological subtypes, and heterogeneity groups.

Results: A positive σ-ADC correlation exists in thoracic lesions, influenced by solidity, malignancy, histological subtype and heterogeneity.

Impact: This study informs the positive relationship between σ and ADC in thoracic lesions, highlights the factors that influence this relationship, and the importance of integrating σ and ADC in evaluating lesion microarchitecture.

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