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Abstract #3305

ULTRA2: a novel system for multi-focal, low-intensity focused ultrasound neuromodulation and whole-brain, ultra-high field MRI at 7T

Daniel Wenz1,2, Ludwig Tiston1,2,3, Jocelyn Philippe4, Katarzyna Pierzchala1,2, and Rares Salomir5,6
1CIBM Center for Biomedical Imaging, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL Swiss Federal Institute of Technology, Lausanne, Switzerland, 3University of Uppsala, Uppsala, Sweden, 4Signal Processing Laboratory 5, EPFL Swiss Federal Institute of Technology, Lausanne, Switzerland, 5Image Guided Interventions Laboratory, Univeristy of Geneva, Geneva, Switzerland, 6Radiology Department, University Hospitals of Geneva, Geneva, Switzerland

Synopsis

Keywords: Hybrid & Novel Systems Technology, Hybrid & Novel Systems Technology, Ultrasound neuromodulation

Motivation: More than 970 million people worldwide suffer from neuropsychiatric disorders. This calls for novel and effective treatment strategies, which would lighten the socio-economic burden and improve the quality of human life.

Goal(s): To develop ULTRA2 - an innovative hardware system for high-precision, multi-focal, low-intensity focused ultrasound neuromodulation and whole-brain MRI at 7T.

Approach: Numerical simulations, hydrophone measurements and 7T MRI experiments were carried out to evaluate performance of both subsystems (radio frequency and ultrasound).

Results: The data showed that ULTRA2 can be used for focused ultrasound experiments and artifact-free MRI at 7T with impressively high transmit field efficiency and SNR.

Impact: ULTRA2 will enable multi-focal, high-precision LIFU neuromodulation guided using advanced UHF neuroimaging strategies, thereby adding a new dimension to developing non-invasive treatment strategies for neurological and neuropsychiatric diseases.

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Abstract

Keywords