Abstract #3350

Quantitative MRI Mapping of Upper Airway Anatomy and Cerebral Oxygen Metabolism with Concurrent EEG in OSA Patients During Sleep in Scanner

Jeffrey Brandon Dennison¹, Andrew Wiemken², Michael Langham³, Jing Xu⁴, Richard J Schwab², and Felix Wehrli³

¹Radiologu, University of Pennsylvania, Marlton, NJ, United States, ²Sleep Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁴Information Management & Decision-making Science, Shanghai International Studies University, Shanghai, China

Synopsis

Keywords: Pulse Sequence Design, Metabolism

Motivation: Patients with obstructive sleep apnea (OSA) are at increased risk for various disorders, thought to be caused by apnea related disturbances in cerebral oxygen metabolism (CMRO₂).

Goal(s): To evaluate changes in CMRO₂ and upper airway architecture during sleep and in response to apneas in a sample of OSA patients and healthy subjects.

Approach: CMRO₂ and upper airway architecture are evaluated during sleep using a custom MRI sequence, while sleep stage was evaluated by means of concurrently recorded EEG.

Results: OSA-patients experienced disturbances in CMRO₂ during sleep including a larger sleep-stage dependent decrease in CMRO₂ over healthy controls.

Impact: Seeing how the upper airway becomes obstructed during sleep may be valuable for surgical treatment planning. Further, identification of the neurometabolic consequences of OSA can enhance our basic understanding of neuro-and cardiovascular risk.

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