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Abstract #3418

Study on the correlation between alterations in brain metabolites and gut microbiota in patients with IBD

jun wang1, Guangyao Liu1, Kai Ai2, and Jing Zhang1
1Department of Magnetic Resonance, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China, 2Department of Clinical and Technical Support, Philips Healthcare, Xi’an, China

Synopsis

Keywords: Data Processing, Neuroinflammation

Motivation: The mechanisms through which gut microbiota alterations influence changes in brain metabolites in inflammatory bowel disease (IBD) remain poorly understood.

Goal(s): To investigate the relationship between levels of brain metabolites, specifically GABA and Glx, and gut microbiome alterations, along with clinical symptoms in IBD patients.

Approach: Magnetic resonance spectroscopy (MRS) and 16S rRNA sequencing were employed to assess brain metabolite levels and gut microbiota composition, respectively.

Results: Altered brain metabolites observed in IBD may be associated with dysbiosis of gut microbiota. These abnormalities are linked to sleep disturbances and pain experienced by IBD patients.

Impact: This study establishes a foundation for understanding the interaction mechanisms between gut microbiota and the central nervous system, offering valuable insights into the neural underpinnings of IBD-associated syndromes.

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