Abstract #3488

Definition of a Nigrosome-1 template for characterizing iron accumulation in Parkinson's Disease

Angelina Catrambone¹, Maria Celeste Bonacci², and Maria Eugenia Caligiuri¹

¹Neuroscience Research Center, Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy, ²Neuroscience Research Center, Department of Medical and Surgical Sciences, Università degli Studi Magna Graecia di Catanzaro, Catanzaro, Italy

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: To assess Nigrosome1 characteristics in Parkinson's disease, especially where the structure is not visible.

Goal(s): To build a Nigrosome-1 template that enables to charaterize the region in Parkinson's disease.

Approach: Creation of a symmetric probability map of N1 using optimized non-linear co-registration that accounts for geometric distortion in SWI data. Comparison between manual and automated measurements.

Impact: Assessing Nigrosome1 characteristics in Parkinson's disease, especially where the structure is not visible, will enhance the understanding of the disease and help identifying biomarkers of disease progression and differential diagnosis.

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