Abstract #3499

Validation of acquisition parameters for human cartilage proteoglycan using highly accelerated T1rho for clinical use.

Angela Walls^1,2, Samuel Staude³, Kantat Poonsawat³, Dzenita Muratovic³, Stephanie Withey⁴, Gabriele Bonanno^5,6,7, Andrew M Dwyer^1,2, and Dominic Thewlis³

¹Clinical and Research Imaging Centre, South Australian Health and Medical Institute, Adelaide, Australia, ²Jones Radiology, Adelaide, Australia, ³Centre for Orthopaedic & Trauma Research, Adelaide Medical School, The University of Adelaide, Adelaide, Australia, ⁴Siemens Healthcare Pty Ltd, Adelaide, Australia, ⁵Advanced Clinical Imaging Technology, Siemens Healthcare International AG, Bern, Switzerland, ⁶Institute of Diagnostic and Interventional Neuroradiology, University of Bern, Bern, Switzerland, ⁷Swiss Institute for Translational and Entrepreneurial Medicine, Translational Imaging Centre, Bern, Switzerland

Synopsis

Keywords: Cartilage, Quantitative Imaging

Motivation: Early cartilage degeneration includes change in proteoglycan content not detectable by standard clinical imaging tools but translation of quantitative spin-lattice relaxation time in a rotating frame (T1ρ) MRI has been technically challenging.

Goal(s): We aim to determine optimal spin lock parameters for an in vivo cohort using a prototype compressed sensing 3D T1ρ implementation.

Approach: Six post-surgical specimens imaged with the prototype sequence and combinations of eight spin lock times will be correlated to ground truth histological proteoglycan content.

Impact: Assessment of optimal combination of spin lock times using direct validation to quantitative measures from histology will provide valuable recommendations for clinical cohorts.

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