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Abstract #3518

Variable Flip Angle SPIR for Fat Suppression in APT-weighted Imaging

Holger Eggers1 and Jochen Keupp1
1Philips Innovative Technologies, Hamburg, Germany

Synopsis

Keywords: Fat & Fat/Water Separation, Fat and Fat/Water Separation

Motivation: Fat signal remains a major impediment to the translation of amide proton transfer (APT)-weighted imaging to applications in the body.

Goal(s): The present work aims at improving the extent and uniformity of fat suppression in this domain.

Approach: A spectral presaturation with inversion recovery (SPIR) with variable flip angle is devised for this purpose and explored in proof-of-concept experiments.

Results: The proposed approach is demonstrated to equalize the residual fat signal in measurements with corresponding positive and negative saturation frequency offsets. In the subsequent subtraction, performed as part of the magnetization transfer ratio (MTR) asymmetry analysis, the residual fat signal then cancels out.

Impact: Variable flip angle SPIR may alleviate persisting artifacts from fat signal in APT-weighted imaging without prolonging the acquisition or requiring elaborate postprocessing.

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Keywords